Academic Experience
2016.07-present, PI, Shanghai Institute of Immunity and Infection, CAS
2010-2015, Postdoc, University of California, San Diego
Education
2010, Ph.D., Biochemistry and Molecular Biology, Institute of Biophysics, CAS
2005, Master, Veterinary, Nanjing Agriculture University
2001, Bachelor, Veterinary, Shandong Agriculture University
· The structural basis of the complex between virus proteins and host factors (RNA polymerase II, Transcription factors, et al), which transcriptionally regulate virus replication. (Such as HBV, HIV, et al)
· Structural analysis to identify key interfaces, active sites and design high specific inhibitors or antibodies to prevent or cure certain diseases.
1. Zhou, H., Wang, F., Wang, H., Chen, C., Zhang, T., Han, X., Wang, L. *, Yang, H. * (2017). The conformational changes of Zika virus methyltransferase upon converting SAM to SAH. Oncotarget, 8(9), 14830–14834. (*, Co-Corresponding Author)
2. Wang, L., §, Zhou, Y.,§, Xu, L.,§, Xiao, R.,§, Lu, X., Chen, L., Chong, J., Li, H., He, C., Fu, X-D.*, and Wang, D.* Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex. Nature 523, 621–625 (2015). (§, Co-First Author)
3. Walmacq, C., Wang, L., Chong, J., Scibelli, K., Lubkowska, L., Gnatt, A., Brooks, P. J., Wang, D. * &Kashlev, M. * Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. ProcNatlAcadSci U S A 112, E410-419 (2015).
4. Wang, L., §, Limbo, O., §, Fei, J., Chen, L., Kim, B., Luo, J., Chong, J., Conaway, R. C., Conaway, J. W., Ranish, J. A., Kadonaga, J. T., Russell, P. & Wang, D. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. ProcNatlAcadSci U S A 111, 18566-18571 (2014). (§, Co-First Author)
5. Xu, L., Chen, Y. C., Nakajima, S., Chong, J., Wang, L., Lan, L., Zhang, C. & Wang, D. A Chemical Probe Targets DNA 5- Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression. ChemSci5, 567-574 (2014)
6. Wang, L., Zhang, W., Wang, L., Zhang, X. C., Li, X. &Rao, Z. Crystal structures of NAC domains of human nascent polypeptide- associated complex (NAC) and its alphaNAC subunit. Protein & Cell 1, 406-416 (2010).
Principal Investigator: WANG Lanfeng
Lab Manager: HE Yaling
Graduate Students: WANG Zhaoning, WANG Weiwei, LI Qian, ZHANG Jun