2019-present, Professor, Principal investigator,
2016-2018, Research director, Institut Pasteur, Paris, France
2009-2016, Laboratory chief, Institut Pasteur, Paris, France
Achievements
- Development of a therapeutic cancer vaccine up to phase I clinical trial
- 1st evidence of fetal Breg development and characterization of a biomarker of RSV induced bronchiolitis in newborns.
- 1st demonstration of the capacity of newborn moDC to induce neonatal TH1 reponses. Demonstration of an alternative pathway
for new adjuvant design for pediatric vaccination.
- 1st evidence of fetal development of memory T cell in humans.
- 1st evidence of regulatory of neutrophils. Demonstration provided in the context of TB infection.
- Demonstration that IFNI-IL10 crosstalk suppresses neonatal lethal inflammation.
- 1st evidence of regulatory B cells in a neonatal setting.
1. Zhivaki D, Lo-Man R. T cell memory in utero. Seminars in Immunpathology. 2017;39(6):585-592.(IF=6.5)
2. Zhivaki D, Lemoine S, Lim A, Morva A, Vidalain PO, Schandene L, Casartelli N, Rameix-Welti MA, Herve PL, Deriaud E, Beitz B, Ripaux-Lefevre M, Miatello J, Lemercier B, Lorin V, Descamps D, Fix J, Eleouet JF, Riffault S, Schwartz O, Porcheray F, Mascart F, Mouquet H, Zhang X, Tissieres P, Lo-Man R. Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity. Immunity. 2017;46(2):301-314. (IF 21.5)
3. Zhang X, Zhivaki D, Lo-Man R. Unique aspects of the perinatal immune system. Nature reviews Immunology. 2017;17(8):495-507. (IF=42)
4. Lemoine S, Jaron B, Tabka S, Ettreiki C, Deriaud E, Zhivaki D, Le Ray C, Launay O, Majlessi L, Tissieres P, Leclerc C, Lo-Man R. Dectin-1 activation unlocks IL12A expression and reveals the TH1 potency of neonatal dendritic cells. The Journal of allergy and clinical immunology. 2015;136(5):1355-1368 e1315. (IF=14)
5. Zhang X, Mozeleski B, Lemoine S, Deriaud E, Lim A, Zhivaki D, Azria E, Le Ray C, Roguet G, Launay O, Vanet A, Leclerc C, Lo-Man R. CD4 T cells with effector memory phenotype and function develop in the sterile environment of the fetus. Sci Transl Med. 2014;6(238):238ra272. (IF=17)