Shanghai Institute of Immunity and Infection (SIII), CAS, is focusing on the fundamental research field of infectious disease prevention and control. SIII has built a chain type technological innovation service system and forming The Public Technical Service Center. The Center has four distinct technical facilities: Laboratory Animal Facility, Analytical Core Facility, Electron Microscopy Core Facility, and Pathogen Discovery & Computing Facility. They are deeply integrated and open to sharing, providing efficient and high-quality technical services, and providing strong technical support for building a world-class research institute. The main forms of Public Technical Service Center services include technical consulting, technical services, technical development, technology transfer, and testing services.

The Laboratory Animal Facility was established in October 2013 and is located on the 9th and 10th floors of Block B, Life Science Building, No. 320 Yueyang Road, Shanghai. As a technical support platform for the combination of BSL2/ABSL2/SPF/GF systems , which can simultaneously carry out cell and mouse infections, it not only provides high-quality SPF level mice for use, but also supports the technical chain of equipment from animal breeding, pathogen infection modeling, in vivo imaging, immunopathological analysis, and evaluation of antiviral drugs and vaccines.

The Analytical Core Facility mainly includes delicate and expensive instruments such as optical imaging, flow cytometry, macromolecules, pathology, mass spectrometry, as well as autoclaving and pure water etc.. It can provide technical support and services for image analysis of tissue and cell morphology, flow cytometry analysis and sorting, protein separation, purification and identification, paraffin and frozen section analysis, and upstream process and research and development of antibody vaccines.

The Electron Microscope Core Facility is equipped with a sample preparation room and electron microscopy room with secondary biological protection capabilities, as well as a complete set of high-, medium-, and low-end electron microscopes such as Titan Krios (equipped with GIF K3/Falcon4/Volta Phase Plate), ARM300II (equipped with K3 phase plate and energy filtration), and Talos L120C. The facility also has much equipment for observation and sample preparation, such as Aquilos dual beam, Leica confocal version CLEM, high-pressure freezing, ultrathin sections (UC7/FC7), blot-free plunger (Chameleon), and so on. And it’s equipped with a data processing supercomputing system with dozens of GPU nodes, it can provide technical support and services such as negative staining, ultra-thin sectioning, cryoelectron microscopy (single particle, cryotomography, and microED), etc.

The Pathogen Discovery & Computing Facility is committed to providing technical services such as pathogen isolation and identification, bacterial and viral species preservation, high-throughput sequencing, kit development, and multi-omics data analysis. We have highly integrated core technology platforms into "discovery, identification and detection of emerging infectious diseases, big data analysis, and resource preservation" chain, established effective comprehensive pathogen identification techniques, and provided strong support for the establishment of a high standard cutting-edge scientific research center and the establishment of a new infectious disease prediction and prevention and control system for the research institute.