Space omics is widely regarded as a new frontier field in the field of life sciences, following single-cell sequencing. The emergence of single-cell spatial multi omics technology has made up for the shortcomings of traditional omics research methods in terms of spatial and temporal resolution. It can reveal the heterogeneity of biomolecules at the cellular level, providing a more comprehensive perspective for understanding the functions and regulatory mechanisms of biological systems. At the same time, this technology also helps to discover new cell types and states, as well as reveal the interactions and communication mechanisms between cells. CosMx spatial molecular imaging technology is a spatial in situ single-cell imaging technology launched by NanoString (now Bruker Spatial Biology) at the end of 2022. Currently, it can achieve in situ detection and analysis of RNA or 70+proteins with a resolution of over 6000 plex at single-cell/subcellular level.

CosMx technology has achieved significant application results in fields such as neuroscience, oncology, and developmental biology. For example, in the field of neuroscience, this technology can reveal the spatial distribution and connectivity patterns of neuron types; In the field of oncology, the heterogeneity of tumor cells and the tumor microenvironment can be studied; In the field of developmental biology, it can reveal the determination of cell fate and the process of embryonic development. 

Lecture time: March 14, 2025, 14:00-15:00

Location: B207

Speaker: YANG Han, Bruker Engineer

Lecture contents:

1. Introduction to the current development status of spatial multi omics technology

2. Principle and Progress of CosMx Space Molecular Imaging Technology

3. Sharing of research cases on space molecule imaging technology in various fields 

Contact: HUANG Xunjuan, xjhuang@siii.cas.cn 

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