Academic Experience

2023.10-present, Associate professor, Shanghai Institute of Immunology and infection, CAS

2023.3-2023.9, Research assistant, Shanghai Institute of Immunology and infection, CAS

2019.7-2023.2, Postdoctoral fellow, Shanghai Institute of Immunology and infection, CAS

Education

2016.9-2018.5, joint Ph.D. student, Harvard Medical Collage

2012.9-2018.7, Ph.D., Peking Union Medical Collage & Tsinghua University

Combining cell biology, pathogenology, pharmacology, and various advanced biological imaging techniques, with a focus on the cell cytoskeleton intermediate filaments, we aim to investigate the pathological basis and patterns of pathogen-host cell interactions in the context of pathogen infections. Our goal is to provide new drug targets and treatment strategies for related diseases.

Key areas of research include:

I. Elucidating the mechanisms of interaction between pathogenic microorganisms and host intermediate filament proteins.

II.Studying the dynamic regulation mechanisms of intermediate filament proteins.

Developing new drugs for combating pathogen infections based on novel mechanisms and targets.

Selected publications in the last five years as the first or co-first author:

1.     Zhao S^#, Xu QP^#, Cui YQ^#, et al., Jiu Y. Salmonella hijacks cytoskeletal vimentin via SopB-Cdc42-MEK1/2 to maintain replication vacuoles for efficient infection. Nat Commun. 2023 Jan 30;14(1):478. (IF: 16.6, JCR: Q1)

2.    Miao CL^#, Zhao S^#, et al., Jiu Y. The diverse actions of cytoskeletal vimentin in bacterial infection and host defense. J Cell Sci. 2023 Jan 1;136(1):jcs260509. (IF: 4.0, JCR: Q3)

3.    Ouyang Z^#, Zhao S^#, Yao S^#, et al., Jiu Y. Multifaceted function of myosin-18, an unconventional class of the myosin superfamily. Front Cell Dev Biol. 2021 Feb 9;9:632445. (IF: 6.684, JCR: Q2)

4.    Zhao S^#, Shi X^#, Zhang Y^#, et al, Jiu Y. Myosin-18B promotes mechanosensitive CaMKK2-AMPK-VASP regulation of contractile actin stress fibers. iScience. 2020;23(4):100975. (IF: 5.458, JCR: Q1)

5.    Zhao S^#, Cai J^#, et al., Jiu Y. Different formins restrict localization of distinct tropomyosins on dorsal stress fibers in osteosarcoma cells. Cytoskeleton. 2020;77(1-2):16-24. (IF: 2.141, JCR: Q3)

6.    Zhang N^#, Zhao SS^#, et al., He HW. A novel biphenyl compound IMB-S7 ameliorates hepatic fibrosis in BDL rats by suppressing Sp1-mediated integrin αv expression. Acta Pharmacol Sin. 2020;41(5):661-669. (IF: 6.15, JCR: Q1)

7.    Zhao SS^#, Li NR^#, et al., He HW, Shao RG. D-chiro-inositol effectively attenuates cholestasis in bile duct ligated rats by improving bile acid secretion and attenuating oxidative stress. Acta Pharmacol Sin. 2018 Feb;39(2):213-221. (IF: 4.01, JCR: Q1)