2024-present  Associate professor, Shanghai Institute of Immunity and Infection, CAS

2017-2024  Research assistant, Shanghai Institute of Nutrition and Health, CAS

2012-2017  Research assistant, CAS-MPG Partner Institute of Computational Biology, CAS

2010-2012  Research assistant, Institut Pasteur of Shanghai, CAS

2003-2010  Ph.D., Shanghai Institute of Biochemistry and Cell Biology, CAS

1999-2003  B.S., Shandong Normal University

I. Develop single-cell three-dimensional genome technology and related bioinformatic analysis methods to dissect the dynamics, heterogeneity and regulatory function of higher-order chromatin structure in immune cells;

II. Investigate how higher-order chromatin structures change and how they contribute to the transcription regulation in the process of T cell differentiation, T cell exhaustion and T cell aging; 

III. Identify transposon element (TE) derived new antigens in tumors using single-cell multi-omics data. 

Selected publications

1. Ge Zhang#, Ying Li†, Gang  Wei† . Multi-omic analysis reveals dynamic changes of three-dimensional chromatin architecture during T cell differentiation. Commun Biol. 2023 Jul 24;6(1):773.

2. Xuan Cao#, Yuhao Wen#, Ying Li, Xuying Ma, Qingqing Jing , Lubin Jiang , Gang Wei. PfSET2 Is Involved in Genome Organization of Var Gene Family in Plasmodium falciparum . Microbiol Spectr. 2023 Feb 14;11(1):e0389122.

3. Yihao Liu#, Xuelong Wang, Youwei Zhu, Yizhi Cao, Liwen Wang, Fanlu Li, Yu Zhang, Ying Li, Zhiqiang Zhang, Jiaxin Luo, Xiaxing Deng, Chenghong Peng,T Gang Wei, Hao Chen,and Baiyong Shen. The CTCF/LncRNA-PACERR complex recruits E1A binding protein p300 to induce pro-tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expression. Clin Transl Med. 2022 Feb;12(2):e654.

4. Xiaolong Ma#, Xuan Cao#, Linying Zhu,# Ying Li, Xuelong Wang, Baihua Wu, Gang Wei, Lijian Hui. Pre-existing chromatin accessibility of switchable repressive compartment delineates cell plasticity. Natl Sci Rev. 2022 Jun; 9(6): nwab230.Published online 2021 Dec 31.

5. Binbin Lu#, Meng Liu#, Liang Gu#, Ying Li#, Shijun Shen, Gangqiang Guo, Fei Wang, Xiaohui He, Yuemeng Zhao, Xiaomin Shang, Liping Wang, Guang Yang, Qianshu Zhu, Jun Cao, Cizhong Jiang, Richard Culleton, Gang Wei, Qingfeng Zhang. The Architectural Factor HMGB1 Is Involved in Genome Organization in the Human Malaria Parasite Plasmodium falciparum. mBio. 2021 Apr 27;12(2):e00148-21.

6. Youwei Zhu#, Jiangning Gu#, Ying Li, Chenghong Peng, Minmin Shi, Xuelong Wang, Gang Wei, Ouyang Ge, Di Wang, Bosen Zhang, Jian Wu, Yiming Zhong, Baiyong Shen, Hao Chen. MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes. Cancer Lett .2018 Jan 1:412:59-68.

7. Jiangning Gu#, Wei Xu, Chenghong Peng, Youwei Zhu, Di Wang, Xuelong Wang, Ying Li, Gang Wei, Zhiqiang Zhang, Yiming Zhong, Shulin Zhao, Minmin Shi, Dongfeng Cheng, Xiayang Ying, Jiabin Jin , Hao Chen. Perineural invasion is related to p38 mitogen-activated protein kinase pathway activation and promotes tumor growth and chemoresistance in pancreatic cancer. J Cell Biochem. 2019 Jul;120(7):11775-11783.

8. Youwei Zhu#, Jiangning Gu#, Ying Li, Chenghong Peng, Minmin Shi, Xuelong Wang, Gang Wei, Ouyang Ge, Di Wang, Bosen Zhang, Jian Wu, Yiming Zhong, Baiyong Shen, Hao Chen. MiR-17-5p enhances pancreatic cancer proliferation by altering cell cycle profiles via disruption of RBL2/E2F4-repressing complexes. Cancer Lett .2018 Jan 1:412:59-68.