Shanghai Institut of Immunity and Infection, Chinese Academy of Sciences

Principal Investigator

WANG LanfengPh.D.

Academic title：Principal Investigator
Discipline：Biomedicine
Departments：Structural Biology of Pathogenic Mechanism
Phone：86-21-54923167
E-mail：lanfwang@siii.cas.cn
Mailing Address：Life Science Research Building, 320 Yueyang Road, Xuhui District, Shanghai 200031, P.R. China

Curriculum Vitae

Lanfeng Wang, Ph.D., Professor, Director of Structural Pathogenesis Unit

Dr. Wang obtained his Ph.D. from the Institute of Biophysics, Chinese Academy of Sciences, in 2010. He completed postdoctoral research at the University of California, San Diego, then set up a laboratory for independent study in 2016.

Some critical scientific achievements have been made recently, and related work has been published in high-impact journals such as Nature, NSMB, and PNAS. He led one National Key R&D Program of China as the sub-project leader, hosted one Natural Science Foundation project and one Shanghai Talent project, and undertook another National Key R&D Program of China and one Strategic Priority Research Program of the Chinese Academy of Sciences.

Research Direction

· The structural basis of the complex between virus proteins and host factors (RNA polymerase II, Transcription factors, et al), which transcriptionally regulate virus replication. (Such as HBV, HIV, et al)

· Structural analysis to identify key interfaces, active sites and design high specific inhibitors or antibodies to prevent or cure certain diseases.

Research Progress

1. Zhou, H., Wang, F., Wang, H., Chen, C., Zhang, T., Han, X., Wang, L. *, Yang, H. * (2017). The conformational changes of Zika virus methyltransferase upon converting SAM to SAH. Oncotarget, 8(9), 14830–14834. (*, Co-Corresponding Author)

2. Wang, L., §, Zhou, Y.,§, Xu, L.,§, Xiao, R.,§, Lu, X., Chen, L., Chong, J., Li, H., He, C., Fu, X-D.*, and Wang, D.* Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex. Nature 523, 621–625 (2015). (§, Co-First Author)

3. Walmacq, C., Wang, L., Chong, J., Scibelli, K., Lubkowska, L., Gnatt, A., Brooks, P. J., Wang, D. * &Kashlev, M. * Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. ProcNatlAcadSci U S A 112, E410-419 (2015).

4. Wang, L., §, Limbo, O., §, Fei, J., Chen, L., Kim, B., Luo, J., Chong, J., Conaway, R. C., Conaway, J. W., Ranish, J. A., Kadonaga, J. T., Russell, P. & Wang, D. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. ProcNatlAcadSci U S A 111, 18566-18571 (2014). (§, Co-First Author)

5. Xu, L., Chen, Y. C., Nakajima, S., Chong, J., Wang, L., Lan, L., Zhang, C. & Wang, D. A Chemical Probe Targets DNA 5- Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression. ChemSci5, 567-574 (2014)

6. Wang, L., Zhang, W., Wang, L., Zhang, X. C., Li, X. &Rao, Z. Crystal structures of NAC domains of human nascent polypeptide- associated complex (NAC) and its alphaNAC subunit. Protein & Cell 1, 406-416 (2010).

Laboratory Members

Principal Investigator: WANG Lanfeng

Lab Manager: YANG Renzheng

Graduate Students: WANG Zhaoning, WANG Weiwei, LI Qian, ZHANG Jun