Academic Experience

2012.01-present, Professor, Principal Investigator, Shanghai Institute of Immunity and Infection, CAS, Shanghai, China  

2007.10- 2011.12, Postdoctoral Researcher, Institut Pasteur, France 

Education

2004.10-2007.09, Ph.D., Immunology, University Pairs 6, France  

2000.09-2003.07, M.S., Biochemistry and Molecular Biology, Yangzhou University, China 

1. Molecular mechanisms in B cell fate-decision. 

2. B cell response, targeted intervention and innovative antibody development in human major diseases (SLE, liver cancer and infectious diseases).

3. Role of senescence and metabolism in B cell response.

4. Single-cell Omics study of human major diseases. 

Selected publications

1. Meng XH, Chen ZC, Li T, Nie ZX, Han HH, Zhong S, Yin ZN, Sun  ST, Xie J, Shen J, Xu XR, Gao CX, Ran L, Xu B, Xiang Z, Wang JY, Sun  PF, Xin PF, A XY, Zhang CB, Qiu GW, Gao HL, Bian YQ, Xu ML, Cao BR, Li F, Zheng L, Zhang XM*, Xiao LB*. Role and Therapeutic Potential for Targeting Fibroblast Growth Factor 10/FGFR1 in Relapsed Rheumatoid Arthritis. Arthritis Rheumatol. 2023, doi: 10.1002/art.42674.

2. Fan FF, Gao J, Zhao Y, Wang J, Meng L, Ma JQ, Li T, Han H, Lai JL, Gao ZD, Li XF, Guo R, Cao ZW, Zhang Y*, Zhang XM*, and Chen HQ*. Elevated Mast Cell Abundance is Associated with Enrichment of CCR2+ Cytotoxic T cells and Favorable Prognosis in Lung Adenocarcinoma. Cancer Res. 2023, 83(16): 2690-2703.

3. Meng L, Zha JL, Zhou BJ, Cao L, Jiang CL, Zhu YF, Li T, Lu L, Zhang JQ, Yang H, Feng J, Gu ZF, Tang H, Jiang LB, Li DF*, Lavillette D*, and Zhang XM*. A Spike-destructing human antibody effectively neutralizes Omicron-included SARS-CoV-2 variants with therapeutic efficacy. PLoS Pathog. 2023, 19(1): e1011085.

4. Zhu C, Ma J, Zhu K, Yu L, Zheng B, Rao D, Zhang S, Dong L, Gao Q*, Zhang XM*, and Xie D*. Spatial immunophenotypes predict clinical outcome in intrahepatic cholangiocarcinoma, JHEP Reports. 2023, 5(8): 100762.

5. Bao SH, Chen ZC, Qin DK, Xu HH, Deng XJ, Zhang RX, Ma JQ, Lu ZP, Jiang S, and Zhang XM*. Single-cell profiling reveals mechanisms of uncontrolled inflammation and glycolysis in decidual stromal cell subtypes in recurrent miscarriage. Hum Reprod. 2023, 38(1): 57-74.

6. Ye Y, Chen ZC, Jiang S, Jia FY, Li T, Lu X, Xue, J, Lian XY, Ma JQ, Hao P, Lu LJ, Ye S, Shen N, Bao CD, Fu Q* and Zhang XM*. Single-cell Profiling Reveals Distinct Adaptive Immune Hallmarks in MDA5+ Dermatomyositis with Therapeutic Implications. Nat Commun. 2022, 13: 6458.

(Highlighted in “Nat Rev Rheumatol”. 2023, 19: 3.)

7. Ye Y, Zhang XL, Li T, Ma JQ, Wang R, Wu CM, Wang RC, Bao CD, Ye S, Shen N, Guo Q*, Fu Q* and Zhang XM*. Two Distinct Immune Cell Signatures Predict the Clinical Outcomes in Patients with MDA5 positive Dermatomyositis with Interstitial Lung Disease. Arthritis Rheumatol. 2022, 74: 1822–1832.

(Comment in “Arthritis Rheumatol”. 2022, 74: 1727-1729.)

8. Wu YC, Yang SX, Ma JQ, Chen ZC, Song GH, Rao DN, Cheng YF, Huang SY, Liu YF, Jiang S, Liu JX, Huang XW, Wang XY, Qiu SJ, Xu JM, Xi RB, Bai F, Zhou J, Fan J, Zhang XM*, and Gao Q*. Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level. Cancer Discov. 2022, 12 (1): 134-153.

9. Song GH, Shi Y, Meng L, Ma JQ, Huang SY, Zhang J, Wu YC, Li JX, Lin YP, Yang SX, Rao DN, Cheng YF, Lin J, Ji SY, Liu YM, Jiang S, Wang XL, Zhang S, Ke AW, Wang XY, Cao Y, Ji Y, Zhou J, Fan J*, Zhang XM*, Xi RB*, and Gao Q*. Single-Cell Transcriptomic Analysis Reveals Two Molecularly and Clinically Distinct Subtypes of Intrahepatic Cholangiocarcinoma. Nat Commun. 2022, 13: 1642.

10. Pu WL, Shi X, Yu PC, Zhang MY, Liu ZY, Tan LC, Han PZ, Wang Y, Ji DM, Gan HL, Wei WJ, Lu ZW, Qu N, Hu JQ, Hu XH, Luo ZL, Li HJ, Ji QH, Wang JC, Zhang XM*, and Wang YL. Single-cell transcriptomic analysis of the tumor ecosystems underlying initiation and progression of papillary thyroid carcinoma. Nat Commun. 2021, 12: 6058.

11. Fu Q*, Zhang XM*. From blood to tissue: take a deeper look at B cells in lupus. Cell Mol Immunol. 2021, 18: 2073–2074.

12. Chen ZC, Yang ZR, Yuan XJ, Zhang XM*, and Hao P*. scSensitiveGeneDefine: sensitive gene detection in single-cell RNA sequencing data by Shannon entropy. BMC Bioinformatics. 2021, 22: 211.

13. Song GH, Shi Y, Zhang MY, Goswami S, Afridi S, Meng L, Ma JQ, Chen Y, Lin YP, Zhang J, Liu YM , Jin ZJ , Yang SX, Rao DN, Zhang S, Ke AW, Wang XY, Cao Y, Zhou J, Fan J, Zhang XM*, Xi RB*, and Gao Q*. Global immune characterization of HBV/HCV-related hepatocellular carcinoma identifies macrophage and T cell subsets associated with disease progression. Cell Discov. 2020, 6:90. 

14. Guo L, Cao CM, Goswami S, Huang XY,  Ma LXX,  Guo YC, Yang BL, Li T, Chi YY, Zhang XM* and Wu J*. Tumoral PD-1hiCD8+ T cells are partially exhausted and predict favorable outcome in triple-negative breast cancer. Clin Sci (Lond). 2020, 134 (7): 711–726.

15. Yang HJ*, Ye S, Goswami S, Li T, Wu JW, Cao CM, Ma JQ, Lu B, Pei X, Chen YN, Yu J, Xu HH, Qiu LW, Afridi S, Xiang LB and Zhang XM*. Highly immunosuppressive HLADRhi regulatory T cells are associated with unfavorable outcomes in cervical squamous cell carcinoma. Int J Cancer. 2020, 146: 1993-2006.

16. Ma JQ, Zheng BH, Goswami S, Meng L, Zhang DD, Cao CM, Li T, Zhu FM, Ma LJ, Zhang Z, Zhang SH, Duan M, Chen Q, Gao Q* and Zhang XM*-. PD1^HiCD8⁺T Cells Correlate with Exhausted Signature and Poor Clinical Outcome in Hepatocellular Carcinoma. J ImmunoTher Cancer. 2019, 7:331.

17. Wu CM, Fu Q, Guo Q, Chen S, Goswami S, Sun SH, Li T, Cao XJ, Chu FY, Chen ZC, Liu M, Liu YH, Fu T, Hao P, Hao Y, Shen N, Bao CD* and Zhang XM*. Lupus associated atypical memory B cells are mTORC1-hyperactivated and functionally dysregulated. Ann Rheum Dis. 2019, 78 (8): 1090-1100.

18. Duan M, Goswami S, Shi JY, Wu LJ, Wang XY, Ma JQ, Zhang Z, Shi Y, Ma LJ, Zhang S, Xi RB, Cao Y, Zhou J, Fan J*, Zhang XM* and Gao Q*. Activated and exhausted MAIT cells foster disease progression and indicate poor outcome in hepatocellular carcinoma. Clin Cancer Res.  2019, 25: 3304-3316.

19. Liu M, Guo Q, Wu CM, Sterlin D, Goswami S, Zhang Y, Li T, Bao CD, Shen N, Fu Q* and Zhang XM*. Type I interferons promote the survival and proinflammatory properties of transitional B cells in systemic lupus erythematosus patients. Cell Mol Immunol. 2019, 16:367–379.

20. Zhang Z, Ma LJ, Goswami S, Ma JQ, Zheng BH, Duan M, Liu LZ, Zhang LJ, Shi JY, Dong LQ, Sun YM, Tian LY, Gao Q* and Zhang XM*. Landscape of infiltrating B cells and their clinical significance in human hepatocellular carcinoma. Oncoimmunology.  2019, 8(4):e1571388.

21. Ye Y, Liu M, Tang LH, Du F, Liu YH, Hao P, Fu Q, Guo Q, Yan QR*, Zhang XM*, Bao CD*. Iguratimod Represses B cell Terminal Differentiation Linked with the Inhibition of PKC/EGR1 Axis. Arthritis Res Ther. 2019, 21:92.  DOI: 10.1186/s13075-019-1874-2.