Academic Experience

2013-present  Principal Investigator, Shanghai Institute of Immunity and Infection, CAS  

2006-2012    Postdoctoral Fellow, Emory University

2002-2005    Visiting Scholar, Harvard Medical School 

Education

2002       Ph.D. National University of Singapore, Singapore 

1995       Bsc. Peking University, Beijing, China 

Research Focus/ direction

Virus-host interaction; Viral pathogenesis; EBV-associated lymphomagenesis; Anti-viral and anti-tumor immunity. 

Research progress

1. Define the molecular mechanism of T cell immune control of EBV-associated lymphomas; Engineer EBV-specific T cells and explore the potential application of improved virus-specific T cell immunotherapy in EBV-associated diseases.

2. Define the novel mechanisms of antiviral innate immunity, anti-tumor immunity, and gammaherpesvirus latent infection; Explore the novel antiviral and anti-tumor strategy.

3. Investigate the role of EBV in NK/T cell lymphomagenesis, delineate the pathogenesis of NK/T cell lymphomas.

Selected publications

1.       Yuanting Zheng, Yaqing Liu, Jingcheng Yang, Lianhua Dong, Rui Zhang, Sha Tian, Ying Yu, Luyao Ren, Wanwan Hou, Feng Zhu, Yuanbang Mai, Jinxiong Han, Lijun Zhang, Hui Jiang, Ling Lin, Jingwei Lou, Ruiqiang Li, Jingchao Lin, Huafen Liu, Ziqing Kong, Depeng Wang, Fangping Dai, Ding Bao, Zehui Cao, Xiaozhen Liang,…..Leming Shi. Multi-omics data integration using ratio-based quantitative profiling with Quartet reference materials. Nature Biotechnology (2023). https://doi.org/10.1038/s41587-023-01934-1

2.       Gengxin Zhang, Linlin Kuang, Yan Liu, Congwei Jiang, Ruihao Yang, Quanjie Ly, Kang Sun, Xiaozhen Liang*, Ke Tao.  Efficient Inactivation of Enveloped Viruses Using a Nanoparticle-Based Photodynamic Method. ACS Applied Nano Materials. 2023, In Press.

3.       Zhongshun Liu, Congwei Jiang, Zhangmengxue Lei, Sihan Dong, Linlin Kuang, Chenxu Huang, Ying Gao, Mu Liu, Hui Xiao, Patrick Legembre, Jae U Juang, Huaping Liang, Xiaozhen Liang*. Phospholipase A2 inhibitor and LY6/PLAUR domain-containing protein PINLY regulates type I interferon innate immunity. PNAS, 2022, 119(1); e2111115119.

4.       Ran Jia, Congwei Jiang, Long Li, Chenxu Huang, Lijuan Lu, Menghua Xu, Jin Xu, Xiaozhen Liang*. Interleukin 16 enahnces the host susceptibility to influenza A virus infection. Front Microbiol. 2021 Sep 22; 12:736449.

5.       Jiao Wang, Yexin Zhang, Linlin Kuang, Jie Yang, Chen Xu, Baolin Mu, Jia Li, Peng Lu, Eijie Song, Wendong Wang, Aiguo Wu, Xiaozhen Liang*, Jian Zhang*. Low-voltage driven Ag-Co₃O₄ textile device for multifunctional air cleaning. Chemical Engineering Journal. 2021, 424(15): 130320.

6.       Ding Ma, Si-Yu Chen, Jin-Xiao Ren, Yu-Chen Pei, Cong-Wei Jiang, Shen Zhao, Yi Xiao, Xiao-En Xu, Guang-Yu Liu, Xin Hu, Xiao-Zhen Liang, Ke-Da Yu, Da-Qiang Li, Yi-Zhou Jiang, Zhi-Ming Shao. Molecular Features and Functional Implications of Germline Variants in Triple-Negative Breast Cancer. Journal of the National Cancer Institute, 2021, 113(7): 884–892.

7.       Lin Zhao, Songguo Xue, Zhongyuan Yao, Juanzi Shi, Biaobang Chen, Ling Wu, Lihua Sun, Yao Xu, Zheng Yan, Bin Li, Xiaoyan Mao, Jing Fu, Zhihua Zhang, Jian Mu, Wenjing Wang, Jing Du, Shuai Liu, Jie Dong, Weijie Wang, Qiaoli Li, Lin He, Li Jin, Xiaozhen Liang, Yanping Kuang, Xiaoxi Sun, Lei Wang & Qing Sang. Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development. Protein Cell 11, 921–927 (2020). https://doi.org/10.1007/s13238-020-00756-0

8.       Zhihua Zhang, Bin Li, Jing Fu, Rong Li, Feiyang Diao, Caihong Li, Biaobang Chen, Jing Du, Zhou Zhou, Jian Mu, Zheng Yan, Ling Wu, Shuai Liu, Wenjing Wang, Lin Zhao, Jie Dong, Lin He, Xiaozhen Liang, Yanping Kuang, Xiaoxi Sun, Qing Sang, Lei Wang. Bi-allelic Missense Pathogenic Variants in TRIP13 Cause Female Infertility Characterized by Oocyte Maturation Arrest. Am J Hum Genet. 2020 May 29; S0002-9297(20)30148-8.

9.       Shuai Liu, Zhangmengxue Lei1, Jie Li, Liu Wang, Ran Jia, Zhongshun Liu, Congwei Jiang, Ying Gao, Mu Liu, Linlin Kuang, Zhikang Qian, Dongming Zhou, Samuel H. Speck, Xiaozhen Liang*. Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation. PLoS Pathogens. 2020, 16(7): e1008701.

　　Principal Investigator: LIANG Xiaozhen

　　Research Assistant: KUANG Linlin 

　　M.S-Ph.D. students: WANG Liu, LI Jie, LIU Shuai,LI Long, ZHOU Xingchen 

　　Co-educated M.S-Ph.D. students: DONG Sihan,CAO Ying,JIA Ran