Selected publications

1.    Hongyu Wu#, Li Wang#, Wenjuan Wang, Zhugui Shao, Xin-Ming Jia, Hui Xiao* and Jiangye Chen*. The secretory Candida effector Sce1 licenses fungal virulence by masking the immunogenic b-1,3-glucan and promoting apoptosis of the host cells. mLife 2023 June 26, 2(2):159-177. *Corresponding authors

2.    Chen X, Wang L, Cao L, Li T, Li Z, Sun Y, Ding J, Zhou C, Xie Y, Yue N, Nan J, Jia XM, Peng C, Li H, Yang J*, Xiao H*. Regulation of Anion Channel LRRC8 Volume-Regulated Anion Channels in Transport of 2'3'-Cyclic GMP-AMP and Cisplatin under Steady State and Inflammation. J Immunol. 2021 May 1;206(9):2061-2074. *Corresponding authors

3.    Hu Y, Wen J, Zhang B*, Xiao H*. Precision control of mTORC1 is crucial for the maintenance and IL-13 responsiveness of alveolar macrophages. Int Immunopharmacol. 2021 Jun; 95:107552. *Corresponding authors

4.    Li T, Xie Y, Shi L, Sun Y, Wen J, Deng Z, Zhang H, Li H, Yang J*, Xiao H*. TSC1 Suppresses Macrophage Necroptosis for the Control of Infection by Fungal Pathogen Candida albicans. Immunohorizons. 2021 Feb 17;5(2):90-101. *Corresponding authors

5.    Zhou C, Chen X, Planells-Cases R, Chu J, Wang L, Cao L, Li Z, López-Cayuqueo KI, Xie Y, Ye S, Wang X, Ullrich F, Ma S, Fang Y, Zhang X, Qian Z, Liang X, Cai SQ, Jiang Z, Zhou D, Leng Q, Xiao TS, Lan K, Yang J, Li H, Peng C, Qiu Z*, Jentsch TJ*, Xiao H*. Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity. 2020 May 19; 52: 767-781. *Corresponding authors

6.    Xie Y, Zhao Y, Shi L, Li W, Chen K, Li M, Chen X, Zhang H, Li T, Yu MI, Yao X, Shao D, Ke Z, Li J, Chen Y, Zhang X, Cui J, Cui S, Leng Q, Cadwell K, Li X, Wei H, Zhang H, Li H*, Xiao H*. Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer. J Clin Invest. 2020 Apr 1;130(4):2111-2128. *Corresponding authors

7.    Shi L, Chen X, Zang A, Li T, Hu Y, Ma S, Lü M, Yin H, Wang H, Zhang X, Zhang B, Leng Q*, Yang J*, Xiao H*. TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis. PLoS Biol. 2019 Aug 21;17(8): e3000420. *Corresponding authors

8.    Wang W, Deng Z, Wu H, Zhao Q, Li T, Zhu W, Wang X, Tang L, Wang C, Cui SZ, Xiao H*, Chen J*. A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection. Nat Commun. 2019, Mar 4;10(1):1015. *Corresponding authors

9.    Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, Zhou C, Fang Y, Liu J, Yang J, Chen X, Li T, Zang A, Yin S, Li B, Plumas J, Chaperot L, Zhang X, Xu G, Jiang L, Shen N, Xiong S, Gao X, Zhang Y, Xiao H*. Epigenetic regulator CXXC5 recruit DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017, 214(5):1471-1491. *Corresponding author

10. Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H*. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015, 16:642-652. *Corresponding author

11.  Du M, Liu J, Chen X, Xie Y, Yuan C, Xiang Y, Sun B, Lan K, Chen M, James SJ, Zhang Y, Zhong J, Xiao H*. Casein Kinase II Controls TBK1/IRF3 Activation in IFN Response against Viral Infection. J Immunol. 2015, 194:4477-4488. *Corresponding author

12.  He L, Zang A, Du M, Ma D, Yuan C, Zhou C, Mu J, Shi H, Li D, Huang H, Deng Q, Xiao J, Yan H, Hui L, Lan K, Xiong S, Li X, Huang Z, Xiao H*. mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines. Virologica Sinica. 2015, 30:1-16. *Corresponding author.

13.  Yang C, Guo L, Liu J, Yang J, Zhu K, Xiao H*, Leng Q*. (2015) Non-Classical MHC I-E negatively regulates macrophage activation and Th17 cells in NOD mice. Sci Rep. 5:12941-12949. *Co-corresponding authors.