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Talent
  • Principal Investigator
  • Associate Professor
  • HomeTalentPrincipal Investigator
  • Principal Investigator

    PAN LeiPh.D.

    • Academic title:Principal Investigator
    • Discipline:Immunogenetics
    • Departments:Intestinal Microenvironment and Health
    • Phone:86-21-54923090
    • E-mail:panlei@siii.cas.cn
    • Mailing Address:Life Science Research Building, 320 Yueyang Road, Xuhui District, Shanghai 200031, P.R. China
    Curriculum Vitae

    Academic Experience

    2018-present  Principal Investigator, The Key Laboratory of Molecular Virology and Immunology, Shanghai Institute of Immunity and Infection, CAS 

    2014-2018   Professor, The Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences

    2010-2014   Associate Professor, The Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences

     

    Education

    2010 Ph.D., Cell Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China

    2006-2009  CAS-Stowers joint Ph.D. training programs, Stowers Institute for Medical Research, Kansas City, Missouri, US

    2004      B.S., the College of Life Sciences, Nankai University, Tianjin, China

    Research Direction

    Combing the manipulation of Drosophila and the mouse, at present our lab mainly focus on the regulation of intestinal eco-immunological homeostasis including three aims: 1) Innate immune signaling homeostasis: to identify new regulatory factors and to determine network regulations of mucosal innate immunity, especially to decipher the inter-organ communications to coordinate local-systemic immune signal transduction; 2) Cellular homeostasis: to study the damages initiation and stem cell mediated tissue repair of intestinal epithelia during combating pathogens; 3) Commensal flora homeostasis: to learn corporately the change pattern and the immunological regulation mechanisms of gut commensal microflora and the fat/energy metabolism.


     

    Research Progress

    Selected publications

     

    Yuhui Gao, Shi Yu, Mengdan Chen, Xun Wang,Lei Pan, Bin Wei and Guangxun Meng. cFLIPS regulates alternative NLRP3 inflammasome activation in human monocytes. Cell Mol Immunol (2023). https://doi.org/10.1038/s41423-023-01077-y

     

    Yuanyuan Wang, Yinhe Mao, Xiaoqing Chen, Xinhuang Huang, Zhongyi Jiang, Kaiyan Yang, Lixing Tian, Tong Jiang, Yun Zou, Xiaoyuan Ma, Chaoyue Xu, Zili Zhou, Xianwei Wu, Lei Pan, Huaping Liang, Lin Zhong, Changbin Chen (2023) Homeostatic control of an iron repressor in a GI tract resident. eLife 12:e86075

       

    Miao Zhang, Yueming Ma, Xianglu Ye, Ning Zhang, Lei Pan# and Bing Wang#. TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases. Signal Transduction and Targeted Therapy, 8, 261 (2023). (#Correspondence author)

     

    Xiaofen Wu,Kongyan Niu,Xiaofan Wang,Jing Zhao,Han Wang,Hui Wang,Ting Miao,Yun Yang,Huanhuan Ma,Yaoyang Zhang,Lei Pan,Rui Liu,Hua Bai,Nan Liu. microRNA-252 and FoxO repress inflammaging by a dual inhibitory mechanism on Dawdle mediated TGF-β pathway in Drosophila. GENETICS ,2022, 3;220(3):iyab234

     

    Lei Wang*, Jiaxin Lin*, Junjing Yu, Kaiyan Yang, Li Sun, Hong Tang, Lei Pan. Downregulation of Perilipin1 by the Immune Deficiency Pathway Leads to Lipid Droplet Reconfiguration and Adaptation to Bacterial Infection in Drosophila. Journal of Immunology, 2021, 207: 1-12.

     

    Shuo Yang*, Yaya Zhao*, Junjing Yu*, Zhiqin Fan, Si-tang Gong, Hong Tang, Lei Pan. Sugar Alcohols of Polyol Pathway Serve as Alarmins to Mediate Local-Systemic Innate Immune Communication in Drosophila. Cell Host & Microbe (2019), 10.1016/j.chom.2019.07.001

     

    Yang S, Zhao Y, Yu J, Fan Z, Gong S-T, Tang H, Pan L. Establishment of Viral Infection and Analysis of Host-Virus Interaction in Drosophila Melanogaster. J. Vis. Exp., doi:10.3791/58845 (2018).

     

    Yang S, Yu J, Fan Z, Gong S-T, Tang H, Pan L. 2018. Bub1 facilitates virus entry through endocytosis in a model of Drosophila pathogenesis. J Virol 92:e00254-18 (2018)

     

    Xiaomeng He*, Junjing Yu*, Min Wang, Yang Cheng, Yanan Han, Shuo Yang, Lei Sun, Ying Fang, Si-tang Gong, Zhong Wang, Yang-Xin Fu, Lei Pan# and Hong Tang#. Bap180/Baf180 is required to maintain homeostasis of intestinal innate immune response in Drosophila and mice. Nature Microbiology,2, 17056 (2017). (#Correspondence author)

     

    Pan L*, Wang S*, Lu T, Weng C, Song X, Park J, Sun J, Yang Z, Yu J, Tang H, McKearin D, Chamovitz D, Ni J, Xie T. Protein competition switches the function of COP9 from self-renewal to differentiation. NATURE, 2014; doi:10.1038/nature13562

     

    Yan D, Neumuller RA, Buckner M, Ayers K, Li H, Hu Y, Yang ZD, Pan L, Wang X, Kelley C, Vinayagam A, Binari R, Randklev S, Perkins LA, Xie T, Cooley L, and Perrimon N. A Regulatory Network of Drosophila Germline Stem Cell Self-Renewal. Developmental Cell 2014, 28, 459–473. (Resource article)

     

    Chen J*, Zhao Y*, Zhang C*, Chen H*, Feng J, Chi X, Pan Y, Du J, Guo M, Cao H, Chen H, Wang Z, Pei R, Wang Q, Pan L, Niu J, Chen X, Tang H. Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice.Cell Research,2014;doi:10.1038

     

    Yu J*, He X*, Chen Y, Hao Y, Yang S, Wang L, Pan L#and Tang H#. Myotubularin-related protein 4 (MTMR4) attenuates BMP/Dpp signaling by dephosphorylation of Smad proteins. J BIOL CHEM 2013, 288 (1): 79-88 (#Correspondence author)

     

    Zhang X, Weng C, Li Y, Wang X, Jiang C, Li X, Xu Y, Chen Q, Pan L# and Tang H#.Human Bop is a novel BH3-only member of the Bcl-2 protein family. ProteinCell 2012, 3 (10): 790–801(#Correspondence author)

     

    Wang X*, Pan L*, Wang S, Zhou J, Tang H, Xie T. Histone H3K9 Trimethylase Eggless Controls Germline Stem Cell Maintenance and Differentiation. Plos Genetics 2011, 7(12): e1002426 (co-first author)

     

    Yu J*, Pan L*, Qin X, Chen H, Xu Y, Chen Y, Tang H. MTMR4 attenuates TGFβ signaling by dephosphorylating R-Smads in endosomes. J Biol Chem. 2010 Mar 12;285(11):8454-62. (Co-first Author)

     

    Xie T#, Song X, Jin Z, Pan L, Weng C, Chen S, Zhang N. Interactions between Stem Cells and Their Niche in the Drosophila Ovary. Cold Spring HarbSympQuant Biol2008;73, 39-47. (Annual review)

     

    Pan L, Chen S, Weng C, Call G, Zhu D, Tang H, Zhang N, Xie T. Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary. Cell Stem Cell. 2007;1:458-469.

    Laboratory Members

    Principal Investigator: PAN Lei

    Associate professor:ZHAO Yaya

    Assistant: YAO Yeping

    Ph.D. students: YANG Kaiyan, LIN Jiaxin, WANG Wenqiang, WANG Weina, LI Huaping, ZHANG Miaomiao

    Ph.D. students: YANG Yiwen, LV Yan, ZENG Xiangkang, LU Xiaofu

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    Address: Life Science Research Building 320 Yueyang Road, Xuhui District, 200031
    Tel:86-21-5492 3020Fax:86-21-5492 3044Email:kefachu@siii.cas.cn