Shanghai Institut of Immunity and Infection, Chinese Academy of Sciences

Principal Investigator

LIU XingPh.D.

Academic title：Principal Investigator
Discipline：Immune Response and Immunotherapy
Departments：Anti-infection and Anti-tumor Immunity
Phone：86-21-54923080
E-mail：xingliu@siii.cas.cn
Mailing Address：Life Science Research Building, 320 Yueyang Road, Xuhui District, Shanghai 200031, P.R. China

Curriculum Vitae

Academic Experience

2018-present, Principle investigator, Shanghai Institute of Immunity and Infection, CAS

2016-2018, Instructor, Harvard Medical School
2014-2016, Postdoctoral fellow, Harvard Medical School (Charles A King Fellowship)

2012-2014, Postdoctoral fellow, Shanghai Institute of Biochemistry and Cell Biology, CAS

Education

2007-2012, Ph.D., Shanghai Institute of Biochemistry and Cell Biology, CAS
2003-2007, B.S., East China Normal University (ECNU)

Research Direction

Our lab focuses on host immune response and the associated human diseases (such as sepsis, systemic lupus erythematosus, vitiligo and cancer). By using cell-based infection models and animal diseases models, we have been trying to reveal the underlying molecular and cellular mechanisms and provide insights for the treatment of the associated human diseases. Based on our expertise and experience, our lab will further (1) investigate the molecular mechanisms underlying pyroptosis and inflammasome signaling pathways; (2) identify and test non-canonical inflammasome inhibitors as a novel strategy for preventing or treating sepsis; (3) assess the roles of other members in gasdermin family in protecting host against infection and cancer. These studies will further deepen our understanding of host immune responses against infection and anti-tumor, and provide new therapeutic strategies for the treatment of these diseases.

Research Progress

Selected Publications (*First author, #Corresponding author)

01. Bai Y, Min R, Chen P, Mei S, Deng F, Zheng Z, Jiang C, Miao R, Wu Z, Zhang P, Pan Y, Lieberman J^# and Liu X^#. Disulfiram blocks inflammatory TLR4 signaling by targeting MD-2. Proc Natl Acad Sci U S A. 2023, 120(31): e2306399120.

02. Deng W, Bai Y, Deng F, Pan Y, Mei S, Zheng Z, Min R, Wu Z, Li W, Miao R, Zhang Z, Kupper T, Lieberman J and Liu X^#. Streptococcal pyrogenic exotoxin B cleaves GSDMA and triggers pyroptosis. Nature. 2022; 602:496-502.

03. Zheng Z, Deng W, Bai Y, Miao R, Mei S, Zhang Z, Pan Y, Wang Y, Min R, Deng F, Wu Z, Li W, Chen P, Ma T, Lou X, Lieberman J^#and Liu X^#. The lysosomal Rag-Ragulator complex licenses RIPK1- and Caspase-8-mediated pyroptosis by Yersinia. Science. 2021; 372, eabg0269.

04. Liu X^#, Xia S, Zhang Z, Wu H^#, Lieberman J^#. Channeling inflammation: gasdermins in physiology and disease. Nat Rev Drug Discov. 2021; 20:384-405.

05. Hu J*, Liu X*^#, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth L, Magupalli V, Zhao L, Luo H, Kim J, Lieberman J^# and Wu H^#. Disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nat Immunol. 2020; (7):736-745.

06. Liu X^#, Lieberman J^#. Knocking 'em Dead: Pore-Forming Proteins in Immune Defense. Annu Rev Immunol. 2020; 38:455-485.

07. Zhang Z, Zhang Y, Xia S, Kong Q, Li S, Liu X, Junqueira C, Meza-Sosa K, Mok T, Ansara J, Sengupta S, Yao Y, Wu H, Lieberman J. Gasdermin E suppresses tumor growth by activating anti-tumor immunity. Nature. 2020; 579(7799):415-420.

08. Cui S, Yu Q, Chu L, Cui Y, Ding M, Wang Q, Wang H, Chen Y, Liu X^#, Wang C^#. Nuclear cGAS Functions Non-canonically to Enhance Antiviral Immunity via Recruiting Methyltransferase Prmt5. Cell Rep. 2020; 33(10):108490.

09. Liu X, Fu R, Pan Y, Meza-Sosa K, Zhang Z and Lieberman J*. PNPT1 Release from Mitochondria during Apoptosis Triggers Decay of Poly(A) RNAs. Cell. 2018; 174(1):187-201.e12.

10. Ruan J, Xia S, Liu X, Lieberman J, and Wu H. Cryo-EM structure of the Gasdermin A3 membrane pore. Nature. 2018; 557(7703):62-67.

11. Li S, Hong Z, Wang Z, Li F, Mei J, Huang L, Lou X, Zhao S, Song L, Chen W, Wang Q, Liu H, Cai Y, Yu H, Xu H, Zeng G, Wang Q, Zhu J, Liu X^#, Tan N^#, and Wang C^#. The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING. Cell Rep. 2018; 25(12):3405-3421.e7.

12. Liu X and Lieberman J. How ICE lights the pyroptosis fire. Cell Death Differ. 2017; 24(2):197-199.

13. Pan Y, Tian T, Park C, Lofftus S, Mei S, Liu X, Luo C, O’Malley J, Gehad A, Teague J, Divito S, Fuhlbrigge R, Puigserver P, Krueger J, Hotamisligil G, Clark R, Kupper T. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017; 543(7644):252-256.

14. Liu X, Zhang Z, Ruan J, Pan Y, Magupalli V, Wu H, and Lieberman J. Inflammasome-activated Gasdermin D causes pyroptosis by forming membrane pores. Nature. 2016; 535(7610):153-8.

15. Wittrup A, Ai A, Liu X, Hamar P, Trifonova R, Charisse K, Manoharan M, Kirchhausen T, and Lieberman J. Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown. Nat Biotechnol. 2015; 33(8):870-6.

16. Wang Q*, Liu X*^#, Cui Y, Tang Y, Chen W, Li S, Yu H, Pan Y, and Wang C^#. The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING. Immunity. 2014; 41(6):919-33. Cover Article.

Laboratory Members

Principal Investigator: LIU Xing

Research Associate/Assistant: LOU Xiwen, KANG He

Postdoctoral Fellows: DENG Wanyan, ZHENG Zengzhang, LI Wu, CHEN Pengcheng, DENG Yang

Ph. D. Candidates: BAI Yang, DENG Fan, MIN Rui, WU Zeyu, ZHANG Chao