Shanghai Institut of Immunity and Infection, Chinese Academy of Sciences

HomeTalentPrincipal Investigator

Principal Investigator

JIU YamingPh.D.

Academic title：Principal Investigator
Discipline：Cell Biology and Biophysics
Departments：Cell Biology and Imaging Study of Pathogen Host Interaction
Phone：86-21-54923175
E-mail：ymjiu@siii.cas.cn
Mailing Address：Life Science Research Building, 320 Yueyang Road, Xuhui District, Shanghai 200031, P.R. China

Curriculum Vitae

Academic Experience

2018-present: Principle investigator, Shanghai Institute of Immunity and Infection, CAS

2017-2018: Docent, Department of Bioscience, University of Helsinki, Finland

2010-2017: Postdoctoral fellow, Institute of Biotechnology, University of Helsinki, Finland

Education

2005-2010: Ph.D. Institute of Biophysics, CAS and Huazhong University of Science and Technology, China

2001-2005: B.Sc. Huazhong University of Science and Technology, China

Research Direction

The unit interests lie in fields of cytoskeleton- and intracellular trafficking- centric view of the world at both cellular and behavior level to understand (1) how pathogens target to the cytoskeletal system and membrane trafficking of host to regulate their invasion, duplication, and mobility between host cells; (2) the molecular mechanisms of cytoskeletal interaction and the regulation to cell migration, polarity and mechanosensing; (3) related optical imaging methods.

Research Progress

Selected publications

1. Zhang Y^#, Zhang X^#, Li Z^#, Zhao W^#, Yang H, Zhao S, Tang D, Zhang Q, Liu H, Li H, Li B, Lappalainen P, Cui Z*, Jiu Y* “Single particle tracking reveals SARS-CoV-2 regulating and utilizing dynamic filopodia for viral invasion”. Science Bulletin. Aug 15. doi.: 10.1016/j.scib.2023.08.031. 2023.

2. Xing Y^#, Chen R^#, Li F^#, Xu B, Han L, Jiu Y*, Zhong J*, Zhou G* “Discovery of a fused bicyclic derivative of 4-hydroxypyrrolidine and imidazolidinone as a new anti-HCV agent”. Virology. Jul 20. Doi: 10.1016/j.virol.2023.07.012. 2023.

3. Wang Y^#, Liang H^#, Liu Y^#, Bao Q, Yang S, Xu X, Chen Y, Liu W, Shi X, Shi Y, Liu X, Liu B, Hao H*, Jiu Y*, Liu Y* “Lamin A/C and vimentin as a coordinated regulator during amoeboid migration in microscale confined microenvironments”. Nano Letters. Jul 17. doi: 10.1021/acs.nanolett.3c02096. 2023.

4. Zhao W^#, Zhao S^#, Han Z^#, Ding X^#, Hu G, Qu L, Huang Y, Wang X, Mao H, Jiu Y, Hu Y, Tan J, Ding X*, Chen L*, Guo C*, Li H* “Enhanced detection of fluorescence fluctuations for high-throughput super-resolution imaging”. Nature Photonics. Jun 15. doi: 10.1038/s41566-023-01234-9. 2023.

5. Mei J^#, Huang X^#, Fan C^#, Fang J, Jiu Y* “Cytoskeleton network participates in the anti-infection responses of macrophage”. BioEssays. May 31:e2200225. doi: 10.1002/bies.202200225. 2023.

6. Zhao S#, Xu Q#, Cui Y#, Yao S, Jin S, Zhang Q, Wen Z, Ruan H, Liang X, Chao Y, Sansonetti P, Wei K*, Tang H*, Jiu Y* “Salmonella effector SopB reorganizes cytoskeletal vimentin to maintain replication vacuoles for efficient infection”. Nature Communications. Jan 30;14(1):478. doi: 10.1038/s41467-023-36123-w. 2023.

7. Zhang Y#, Zhao S, Li Y, Feng F, Li M, Xue Y, Cui J, Xu T, Jin X*, Jiu Y* “Host cytoskeletal vimentin serves as a structural organizer and an RNA-binding protein regulator to facilitate Zika viral replication”. Proc Natl Acad Sci U S A. Feb 22;119(8):e2113909119. doi: 10.1073/pnas.2113909119. 2022.

8. Fan C#, Shi X, Zhao K, Wang L, Shi K, Liu Y, Li H, Ji B, Jiu Y* “Cell migration orchestrates migrasome formation by shaping retraction fibers” Journal of Cell Biology. Apr 4;221(4): e202109168. doi: 10.1083/jcb.202109168. 2022. (Cover paper, also the annual top ten special report paper)

9. Shi X#, Tang D#, Xing Y#, Zhao S, Fan C, Zhong J, Cui Y*, Shi K*, Jiu Y* “Actin nucleator formins regulate the tension-buffering function of caveolin-1” Journal of Molecular Cell Biology. Jan 29;13(12):876-888. doi: 10.1093/jmcb/mjab070. 2021. (Cover paper)

10. Liu W#, Tang D#, Xu X, Liu Y*, Jiu Y* “How physical factors coordinate virus infection： a perspective from mechanobiology”. Frontiers in Bioengineering and Biotechnology. Oct 29;9:764516. doi: 10.3389/fbioe.2021.764516. 2021.

11. Shi X#, Wen Z, Wang Y, Liu Y, Shi K, Jiu Y* “Feedback-driven mechanisms between phosphorylated caveolin-1 and contractile actin assemblies instruct persistent cell migration” Frontiers in Cell and Developmental Biology. Apr 12;9:665919. doi: 10.3389/fcell.2021.665919. 2021.

12. Wen G#, Li S, Wang L, Chen X, Sun Z, Liang Y, Jin X, Xing Y, Jiu Y, Tang Y, Li H* “High-fidelity structured illumination microscopy by point-spread-function engineering” Light: Science & Application. Apr 1;10(1):70. doi: 10.1038/s41377-021-00513-w. 2021.

13. Zhang Y#, Wen Z, Shi X, Liu Y, Eriksson J*, Jiu Y* “The diverse roles and dynamic rearrangement of vimentin during virus infection”. Journal of Cell Science. Nov 5;134(5):jcs250597. doi: 10.1242/jcs.250597. 2020.

14. Zhao S#, Shi X#, Zhang Y#, Wen Z, Cai J, Gao W, Xu J, Zheng Y, Ji B, Cui Y, Shi K, Liu Y, Li H, Jiu Y*, “Myosin-18B promotes mechanosensitive CaMKK2-AMPK-VASP regulation of contractile actin stress fibers”. iScience. Apr 24;23(4):100975. doi: 10.1016/j.isci.2020.100975. 2020.

15. Wen Z#, Zhang Y#, Lin Z, Shi K, Jiu Y*, “Cytoskeleton - a crucial key in host cell for coronavirus infection”. Journal of Molecular Cell Biology. Dec;12(12):968-79. doi: 10.1093/jmcb/mjaa042. 2020.

16. Xing Y#, Wen Z#, Gao W, Lin Z, Zhong J, Jiu Y*, “Multifaceted functions of host cell caveolae/caveolin-1 in virus infections”. Viruses. Apr 26; 12(5):E487. doi: 10.3390/v12050487. 2020.

17. Kumari R#, Jiu Y, Carman P, Tojkander S, Kogan K, Varjosalo M, Gunning P, Dominguez R, Lappalainen P* “Tropomodulins control balance between protrusive and contractile structures in migrating cells by stabilizing actin-tropomyosin filaments”. Current Biology. Mar 9;30(5):767-778.e5. doi: 10.1016/j.cub.2019.12.049. 2020.

18. Zhao S#, Cai J#, Zhang X, Cui J, Jiu Y* “Different formins restrict localization of distinct tropomyosins on dorsal stress fibers in osteosarcoma cells”. Cytoskeleton (Hoboken). Jan;77(1-2):16-24. doi: 10.1002/cm.21588. 2020.

19. Jiu Y#*, Kumari R, Fenix A, Schaible N, Liu X, Varjosalo M, Krishnan R, Burnette D, Lappalainen P* “Myosin-18B promotes the assembly of myosin II stacks to drive maturation of contractile actomyosin bundles”. Current Biology. Jan 7;29(1):81-92.e5. doi: 10.1016/j.cub.2018.11.045. 2019.

20. Shi X#, Zhao S, Cai J, Wong G, Jiu Y* “Active FHOD1 promotes the formation of functional actin stress fibers”. Biochemical Journal. Oct 30;476(20):2953-2963. doi: 10.1042/BCJ20190535. 2019. (Cover paper)

21. Li J#, Gao W#, Zhang Y#, Cheng F, Eriksson J, Etienne-Manneville S, Jiu Y* “Engagement of vimentin intermediate filaments in hypotonic stress”. Journal of Cellular Biochemistry. Aug;120(8):13168-13176. doi: 10.1002/jcb.28591. 2019.

22. Deng L#, JiangW, Wang X, Merz A, Hiet M, ChenY, Pan X, Jiu Y, Yang Y, Yu B, He Y, Tu Z, Niu J, Bartenschlager R, Long G* “Syntenin regulates hepatitis C virus sensitivity to neutralizing antibody by promoting E2 secretion through exosomes”. Journal of Hepatology. Jul;71(1):52-61. doi: 10.1016/j.jhep.2019.03.006. 2019.

23. Li J#, Zou Y, Li Z, Jiu Y* “Joining actions: crosstalk between intermediate filaments and actin orchestrates cellular physical dynamics and signaling”. Science China Life Sciences. Oct;62(10):1368-1374. doi: 10.1007/s11427-018-9488-1. 2019.

24. Zhang Y#, Gao W, Li J, Wu W, Jiu Y* “The role of host cytoskeleton in flavivirus infection”. Virologica Sinica. 2019 Feb;34(1):30-41. doi: 10.1007/s12250-019-00086-4. 2019. 封面论文

25. Liu X#, Salokas K, Tamene F, Jiu Y, Weldatsadik R, Varjosalo M* “An AP-MS- and BioID-compatible MAC-tag enables comprehensive mapping of protein interactions and subcellular localizations”. Nature Communications. Mar 22; 9(1):1188. doi: 10.1038/s41467-018-03523-2. 2018.

26. Jiu Y#*, Peranen J, Schaible N, Cheng F, Eriksson J, Krishnan R, Lappalainen P* “Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA”. Journal of Cell Science. Jan 18; 130(5): 892-902. doi: 10.1242/jcs.196881. 2017.

27. Jiu Y#, Lehtimaki J, Tojkander S, Cheng F, Jaalinoja H, Liu X, Varjosalo M, Eriksson J, Lappalainen P* “Bidirectional interplay between vimentin intermediate filaments and contractile actin stress fibers”. Cell Reports. Jun 16; 11(10):1511-1518. doi: 10.1016/j.celrep.2015.05.008. 2015.

28. Weinheimer I#, Jiu Y#, Rajami M#, Matilainen O, Kallijarvi J, Cuellar W, Lu R, Saarma M, Holmberg C, Jantti J, Valkonen J* “Suppression of RNAi by dsRNA-degrading RNaseIII enzymes of viruses in animals and plants”. PLoS Pathogens. Mar 6; 11(3):e1004711. doi: 10.1371/journal.ppat.1004711. 2015.

29. Yu Y#, Wang L#, Jiu Y#, Zhan Y, Liu L, Xia Z, Song E, Xu P*, Xu T* “HID-1 is a novel player in the regulation of neuropeptide sorting”. Biochemical Journal. Feb 24; 434(3):383-390. doi: 10.1042/BJ20110027. 2011.

30. Jiu Y#, Yue Y#, Yang S#, Liu L, Yu J, Zhang R, Wu Z*, Xu T* “Insulin-like signaling pathway for decision making behavior in C. elegans”. Protein Cell. Jan;1(1):75-81. doi: 10.1007/s13238-010-0003-4. 2010.

31. Jiu Y#, Hu Z#, Liu J#, Wu Z*, Xu T* “α-LTX and α-LTXN4C induce [Ca2+]i elevation through different mechanisms in pancreatic β cells”. Chinese Science Bulletin. Jan; 51(2):158-163. doi: 10.1007/s11434-005-1029-5. 2006.

Laboratory Members

Positions

We are currently looking for postdocs and research assistants, please email to PI if you are interested.