LIU BoPh.D.
- Academic title：Principal Investigator
- Discipline：Immunology
- Departments：Innate Immunity and Inflammatory Disease
- Phone：86-21-54923105
- E-mail：bliu@siii.cas.cn
- Mailing Address：Life Science Research Building, 320 Yueyang Road, Xuhui District, Shanghai 200031, P.R. China
Academic Experience
2020-present Professor and Principal investigator, Shanghai Institute of Immunity and Infection, CAS
2017-2020 Associate Specialist, University of California Berkeley, Berkeley, CA, USA
2013-2017 Postdoctoral Scholar, University of California Berkeley, Berkeley, CA, USA
2010-2013 Research Associate, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
Education
2003 B.S., School of Life Sciences, Fudan University, Shanghai, China
2010 Ph.D. in Biochemistry and Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China
Ni, H., Wang, Y., Yao, K., Wang, L., Huang, J., Xiao, Y., Chen. H., Liu, B.*, Yang, C.*, and Zhao J.* Thioesterase PPT1 regulates systemic lupus erythematosus via an endosomal TLR9 palmitoylation cycle. Nature Communications (In revision).
Guo, J., Zhu, Y., Ma, X., Shang, G., Liu, B.* and Zhang, K.* (2023). Virus Infection and mRNA Nuclear Export. International Journal of Molecular Sciences 24, 12593.
Chen, F., Hou, W., Yu, X., Wu, J., Li, Z., Xu, J., Deng, Z., Chen, G., Liu, B., Yin, X., Yu, W., Zhang, L., Xu, G., Ji, H., Liang, C., and Wang Z. (2023). CBX4 deletion promotes tumorigenesis under KrasG12D background by inducing genomic instability. Signal Transduction and Targeted Therapy 8, 343.
Lind, N.#, Rael, V.#, Pestal, K.#, Liu, B., and Barton, G. (2022). Regulation of nucleic acid-sensing Toll-like receptors. Nature Reviews Immunology 22(4), 224-235.
Wang, Z., Fang, Z., Chen, G., Liu, B., Xu, J., Li, F., Li, F., Liu, H., Hang, H., Sun, Y., Tian, G., Chen, H., Xu, G., Zhang, L., Hu, L.*, and Ji, H.* (2021). Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway. Neoplasia 23, 222-233.
Majer, O.#, Liu, B.# *, Kreuk, L., Krogan, N., and Barton, G.* (2019). Unc93b1 recruits Syntenin-1 to dampen TLR7 signaling and prevent autoimmunity. Nature 575, 366-370.
Majer, O., Liu, B., Woo, B., Kreuk, L., Van Dis, E., and Barton, G. (2019). Release from Unc93b1 in endosomes reinforces the compartmentalized activation of select nucleic acid-sensing TLRs. Nature 575, 371-374.
Majer, O., Liu, B., and Barton, G. (2017). Nucleic acid-sensing TLRs: trafficking and regulation. Current Opinion in Immunology 44, 26-33.
Mardaryev, A., Liu, B., Rapisarda, V., Poterlowicz, K., Malashchuk, I., Rudolf, J., Sharov, A., Jahoda, C., Fessing, M., Benitah, S., Xu, G., and Botchkarev, V. (2016). Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. Journal of Cell Biology 212(1), 77-89.
Liu, B., Liu, Y., Du, Y., Mardaryev, A., Yang, W., Chen, H., Xu, Z., Xu, C., Zhang, X., Botchkarev, V., Zhang, Y., and Xu, G. (2013). Cbx4 regulates the proliferation of thymic epithelial cells and thymus function. Development 140, 780-788. (#Contributed equally).
Du, Y., Liu, B., Guo, F., Xu, G., Ding, Y., Liu, Y., Sun X., and Xu, G. (2012). The essential role of Mbd5 in the regulation of somatic growth and glucose homeostasis in mice. PLoS ONE 7, e47358.
Liu, B., Lin, Y., Darwanto, A., Song, X., Xu, G., and Zhang, K. (2009). Identification and characterization of propionylation at histone H3 lysine 23 in mammalian cells. Journal of Biological Chemistry 284, 32288-32295.
Principal Investigator: LIU Bo,
Lab Manager: NIE Yaxing
Postdoctoral Scholar: LIU Wei
PhD students: MENG Yifan, NING Bo, WANG Huilin, WANG Yinuo, ZHU Yaru, YU Jundan, PU Congli (Joint)
Master students: MAO Rui (Joint)
Rotation students: WANG Chaoyuan, ZHAO Xiangtan
Address: Life Science Research Building 320 Yueyang Road, Xuhui District, 200031
Tel：86-21-5492 3020Fax：86-21-5492 3044Email：kefachu@siii.cas.cn
