Lipids are fundamentally important in all life forms, but many basic questions about lipids are not answered due to the lack of available techniques. Our lab is interested in combining the skills of synthetic chemistry, biochemistry and cell biology to uncover new principles and mechanisms regulating local lipid metabolism and transport. We are also keen on translating acquired knowledge to advance our understanding of lipids during the host-microbiota interactions.

Selected Publications (^*First author, ^#Corresponding author)

S Feng*; T Harayama; D Chang; JT Hannich; N Winssinger; H Riezman, Lysosome targeted

photoactivation reveals local sphingosine metabolism signature. Chem. Sci. 2019; 10, 2253-2258 (cover picture, featured as 2019 Chemical Science HOT Article Collection)

S Feng*; T Harayama; S Montessuit; F David; N Winssinger; JC Martinou; H Riezman,

Mitochondria-specific photoactivation to monitor local sphingosine metabolism and functions.

eLife 2018; 7, e34555

M Schifferer*; S Feng*; F Stein; C Tischer; C Schultz, Reversible chemical dimerizerinduced

recovery of PIP2 levels moves clathrin to the plasma membrane. Bioorg. Med. Chem., 2015, 23, 2862-2867. (*co-first author)

S Feng; V Laketa; F Stein; A Rutkowska; A MacNamara; S Depner; U Klingmueller; J

Saez-Rodriguez; C Schultz, A rapidly reversible chemical dimerizer system to study lipid

signalling in living cells. Angew. Chem. Int. Ed., 2014, 53, 6720-6723 (selected as a VIP

paper, featured in ChemBioChem)