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Talent
  • Principal Investigator
  • Associate Professor
  • HomeTalentPrincipal Investigator
  • Principal Investigator

    SHAO MenglePh.D.

    • Academic title:Principal Investigator
    • Discipline:Metabolic regulation
    • Departments:Microbiota and Metabolic Disease
    • Phone:
    • E-mail:mlshao@siii.cas.cn
    • Mailing Address:Life Science Research Building, 320 Yueyang Road, Xuhui District, Shanghai 200031, P.R. China
    Curriculum Vitae

    Academic Experience:

    2021.07-present, Principle investigator, Shanghai Institute of Immunity and Infection, CAS

    2019.02-2021.06, Assistant instructor, University of Texas Southwestern Medical Center
    2013.11-2019.01, Postdoctoral researcher, University of Texas Southwestern Medical Center

    2013.02-2013.10, Postdoctoral researcher, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, CAS

     

    Education:

    2007.09-2013.01, Ph.D., Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, CAS
    2003.09-2007.07, BS, Shanghai Jiao Tong University

    Research Direction

    The global prevalence of obesity places a growing number of individuals on the risk of developing chronic metabolic disease. However, effective therapeutics for the prevention and treatment of obesity are still very limited, which urges new discoveries of new therapeutic targets and strategies to combat against obesity and its comorbidities.

    One of the determinants of metabolic health in obesity is the mode by which metabolic organs (e.g. adipose tissue, liver, etc.) remodel in the setting of excessive caloric intake. Our labs focus on the investigation the key events of metabolic organ remodeling in multiple physiological and pathological settings. Our previous and ongoing projects employ state-of-the-art approaches including inducible genetic models, single-cell/nucleus technologies, multi-omics analysis, and advanced imaging systems to extensively explore the plasticity, complexity and heterogeneity of metabolic organs at cellular and molecular levels. We aim to elucidate how the key factors (such as nutrient status and host-microbial homeostasis) determine metabolic organs remodeling modes, with the hope of opening new pharmacological opportunities of utilizing these regulatory mechanisms to promote metabolic organ health and maintain metabolic health in obesity.

    Research Progress

    Selected publications

     

    1. Fu T, Sun W, Xue J, Zhou Z, Wang W, Guo Q, Chen X, Zhou D, Xu Z, Liu L, Xiao L, Mao Y, Yang L, Yin Y, Zhang X, Wan Q, Lu Bin, Chen Y, Zhu M, Scherer PE, Fang L, Piao H, Shao M#, Gan Z#. Proteolytic rewiring of mitochondria by LONP1 directs cell identity switching of adipocytes. Nat Cell Biol. 2023;25(6):848-864 (# Co-corresponding author) (Commented by Nat Cell Biol)

    2. Shan B*, Barker CS*, Shao M*, Zhang Q, Gupta RK, Wu Y. Multilayered omics reveal sex- and depot-dependent adipose progenitor cell heterogeneity. Cell Metab. 2022;34:783-799 (* Co-first author)

    3. Shao M, Hepler C, Zhang Q, Shan B, Vishvanath L, Henry GH, Strand DW, Gupta RK. Pathological HIF1 Signaling Drives Adipose Progenitor Dysfunction in Obesity. Cell Stem Cell. 2021;28(4):685-701 (Cover story; commented by Cell Stem Cell)

    2. Shan B*, Shao M*, Zhang Q, Hepler C, Paschoal VA, Barnes SD, Vishvanath L, An YA, Malladi VS, Strand DW, Gupta OT, Oh D, Gupta RK. Perivascular Mesenchymal Cells Control Adipose Tissue Macrophage Accrual in Obesity. Nat Metab. 2020;2(11):1332-1349 (* Co-first author) (Highlighted by Nat Rev Endocrinol)

    3. Zhang Z*, Shao M*, Hepler C, Zi Z, Zhao S, An YA, Zhu Y, Ghaben AL, Wang M, Li N, Onodera T, Joffin N, Crewe C, Zhu Q, Vishvanath L, Kumar A, Xing C, Wang QA, Gautron L, Deng Y, Gordillo R, Kruglikov I, Kusminski CM, Gupta RK, Scherer PE. Dermal Adipose Tissue Has High Plasticity and Undergoes Reversible Dedifferentiation in Mice. J Clin Invest. 2019;129(12):5327-5342 (* Co-first author)

    4. Shao M, Vishvanath L, Busbuso NC, Hepler C, Shan B, Sharma AX, Chen S, Yu X, An YA, Zhu Y, Holland WL, Gupta RK. De novo adipocyte differentiation from Pdgfrb+ preadipocytes protects against pathologic visceral adipose expansion in obesity. Nat Commun. 2018;9:890

    6. Shao M, Ishibashi J, Kusminski CM, Wang QA, Hepler C, Vishvanath L, MacPherson KA, Spurgin SB, Sun K, Holland WL, Seale P, Gupta RK. Zfp423 maintains white adipocyte identity through suppression of the beige cell thermogenic gene program. Cell Metab. 2016;23:1167-1184

    7. Liu Y*, Shao M*, Wu Y, Yan C, Jiang S, Liu J, Dai J, Yang L, Li J, Jia W, Rui L, Liu Y. Role for the endoplasmic reticulum stress sensor IRE1a in liver regenerative responses. J Hepatol. 2015;62:590-598 (* Co-first author)

    8. Shao M*, Shan B*, Liu Y, Deng Y, Yan C, Wu Y, Mao T, Qiu Y, Zhou Y, Jiang S, Jia W, Li J, Li J, Rui L, Yang L, Liu Y. Hepatic IRE1? regulates fasting-induced metabolic adaptive programs through the XBP1s-PPAR signalling. Nat Commun. 2014;5:3528

    10. Mao T*, Shao M*, Qiu Y, Huang J, Zhang Y, Song B, Wang Q, Jiang L, Liu Y, Han JD, Cao P, Li J, Gao X, Rui L, Qi L, Li W, Liu Y. PKA phosphorylation couples hepatic inositol-requiring enzyme 1a to glucagon signaling in glucose metabolism. PNAS. 2011;108:15852-15857 (* Co-first author)

    Laboratory Members

    Principal Investigator: SHAO Mengle Shao

    Lab Manager: WANG Xiaojuan

    Assistant Professor: ZHANG Xiaoli

    Postdoc: WAN Qiangyou, CAI Juan

    Graduate Students: WEI Danni, LI Siqi

     

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    Address: Life Science Research Building 320 Yueyang Road, Xuhui District, 200031
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