Academic Experience

2020-present, Principle investigator, Shanghai Institute of Immunity and Infection, CAS

2017-2020, Facility Manager, Department of Molecular BioSciences, University of Texas at Austin, USA
2015-2017, Postdoctoral fellow, UT Southwestern Medical Center, USA
2015-2015, Postdoctoral fellow, Department of Biology, Brandeis University, USA

2014-2015, Postdoctoral fellow, Florida State Univ., USA

Education   

2007-2014, Ph.D., Kasha Institute of Molecular Biophysics, Florida State University, USA

2004-2006, M.S., School of Life Science, Sun Yat-sen(Zhongshan) University
2000-2004,B.S., Sun Yat-sen(Zhongshan) University

Our lab focuses on cryo-EM technology development and its application,more on cryo-Electron Tomography (cryo-ET). Specifically, we’re developing a high-throughput high-resolution workflow combining cryo-fluorescence LM, FIB, and cryo-ET aiming at in-situ structural biology for the interaction of pathogen and host. In addition, we’re interested in atomic resolution Single-particle technology for dynamic macromolecules. Plus, we’re interesting in multi-modality to investigate scientific problems, e.g. CXMS-cryoEM.

Selected publications

·         Shubing Tang, Min Li, Lixiang Chen, Aguang Dai, Zhi Liu, Mang Wu, Jingyi Yang , Hongyun Hao, Jingdan Liang, Xiaohui Zhou, Zhikang Qian, Codelivery of SARS-CoV-2 Prefusion-Spike Protein with CBLB502 by a Dual-Chambered Ferritin Nanocarrier Potentiates Systemic and Mucosal Immunity, ACS Applied Bio Materials 2022

·          Weiwei Wang, Zhaoning Wang, XiunaYang, Yan Gao, Xiang Zhang, Long Cao, Aguang Dai, Jin Sun, Lei Sun, Lubing Jiang, Zhenguo Chen, Lanfeng Wang, The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum, Cell Discovery 2021

·         Long Gui, Kangkang Song, Douglas Tritschler, Raqual Bower, Si Yan, Aguang Dai, Katherine Augspurger, Jason Sakizadeh, Magdalena Grzemska, Thomas Ni, Mary E. Porter, Daniela Nicastro, et al., Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex, Proceedings of National Academy of Sciences of the University States of America 2019

·         Aguang Dai, Feng Ye, Dianne W. Taylor, Guiqing Hu, Mark H. Ginsberg, and Kenneth A. Taylor. The structure of a full-length membrane-embedded integrin bound to a physiological ligand, Journal of Biological Chemistry 2015

·         Liu Shuyu, He Jian, Li Kunpeng, Dai Aguang, Cai Changjie, Zhang Jingqiang, Three-dimensional structure of the hepatitis B core antigen particle truncated at residue 154, China Life Science, 2011

·         Liu Shuyu, He Jian, Shih Chiaho, Li Kunpeng, Dai Aguang, Zhou ZhengHong, Zhang Jingqiang, Structural comparisons of hepatitis B core antigen particles with different C-terminal lengths, Virus Research, 2010

·         Li Zhihong, He Jian, Huang Xiaojun, Dai Aguang, Cheng Lingpeng, Shao Dingyong, Zhang Jingqiang, The truncated virus-like particles of C6/36 cell densovirus: implications for the assembly mechanism of brevidensovirus, Virus Research, 2008