MAO MiaoweiPh.D.
- Academic title：Principal Investigator
- Discipline：Molecular biology and RNA biology
- Departments：RNA Synthetic Biology
- Phone：86-21-54923137
- E-mail：maomiaowei@siii.cas.cn
- Mailing Address：Life Science Research Building, 320 Yueyang Road, Xuhui District, Shanghai 200031, P.R. China
Academic Experience
2024.02-present Principal Investigator, Shanghai Institute of Immunity and Infection, CAS
2022.10-2024.01 Associate Professor, Shanghai Institute of Nutrition and Health, CAS
2020.04-2022.10 Postdoctoral fellow, Shanghai Institute of Nutrition and Health, CAS
2018.09-2020.03 Postdoctoral fellow, Shanghai Institutes for Biological Sciences, CAS
Education
2015.11-2016.10 Joint training Ph.D., National Institutes of Health, US
2014.10-2015.11 Joint training Ph.D., University of North Carolina at Chapel Hill
2013.03-2018.09 Ph.D., East China University of Science and Technology
2010.09-2013.02 Master, East China University of Science and Technology
2006.09-2010.06 B.S., East China University of Science and Technology
According to the central dogma of molecular biology, RNA plays an important role in genetic code transmission and also involved in multiple cellular processes, including transcription, splicing, transport, translation, and degradation. Dysregulation of RNA may interfere with normal metabolic processes, causing many human diseases. Our group focuses on the fields of RNA biology and synthetic biology, utilizing advanced technique from molecular biology, protein engineering, and computational biology to develop gene expression regulatory tools; Studying the underlying biological mechanisms with the new methods. The research conducted in our laboratory aims to contribute to human health and well-being.
Developing gene therapies for common human genetic diseases;
Development and application of a CRISPR free RNA targeting system;
Application of circular RNA vaccine technology;
Development of new protein degradation system.
Selected Publications (#First author, *Corresponding author)
1. Mao, M.#, Qian, Y.#, Zhang, W.#, Zhou, S., Wang, Z., Chen, X.*, & Yang, Y.* (2023). Controlling protein stability with SULI, a highly sensitive tag for stabilization upon light induction. Nature Communications, 14(1), 2172.
2. Han, W.#, Huang, W.#, Wei, T., Ye, Y., Mao, M.*, & Wang, Z.* (2022). Programmable RNA base editing with a single gRNA-free enzyme. Nucleic Acids Research, 50(16), 9580-9595.
3. Mao, M., Hu, Y., Yang, Y., Qian, Y., Wei, H., Fan, W., ... & Wang, Z. (2018). Modeling and predicting the activities of trans-acting splicing factors with machine learning. Cell Systems, 7(5), 510-520.
4. Zhao, Y. Y.#, Mao, M. W.#, Zhang, W. J.#, Wang, J., Li, H. T., Yang, Y., Wang, Z.F.* & Wu, J. W. * (2018). Expanding RNA binding specificity and affinity of engineered PUF domains. Nucleic Acids Research, 46(9), 4771-4782.
5. Yang, Y.#, Fan, X.#, Mao, M.#, Song, X., Wu, P., Zhang, Y., ... & Wang, Z. (2017). Extensive translation of circular RNAs driven by N6-methyladenosine. Cell Research, 27(5), 626-641.
Patent
Photosensitive degradant desVVD with stability regulated by blue light in eukaryotic cell，Patent No: ZL 201410236036.X
A reporter system for screening drugs targeting RNA repeat expansion，Patent No：CN202310875071.5
A reporter system for screening drugs targeting RNA repeat expansion，Patent No：PCT/CN2024/106008
Principal Investigator: MAO Miaowei
Research Assistant: LI Yuchen, XING Shuli
Postdoctoral Fellows: WEI Tong (visiting)
Students: SUN Yun, SUN Yuchang, JIA Zengyu
Visiting Scientists: REN Yuxin, HAN Lili
Address: Life Science Research Building 320 Yueyang Road, Xuhui District, 200031
Tel：86-21-5492 3020Fax：86-21-5492 3044Email：kefachu@siii.cas.cn
