Research Progress--Shanghai Institut of Immunity and Infection, Chinese Academy of Sciences

08

2011-12

Penicillium marneffei-stimulated dendritic cellsenhance HIV-1 trans-infection and promote viral infection by activating primary CD4+ T cells

Penicillium marneffei (P. marneffei) is considered an indicator pathogen of AIDS, and the endemicity and clinical features of P. marneffei have been described. While, how the co-infection of P. marneffei exacerbate deterioration of the immune response remains poorly understood.
　　Professor WANG...

06

2011-12

New mechanism of cross-species adaptation for avian influenza virus

Prof. SUN Bing with his team at Shanghai Institute of Pasteur, CAS, found that PB1 of avian influenza A virus contributes to higher polymerase activity than PB1 from human influenza A virus, and 473V and 598P are responsible for this role. This founding indicates a new mechanism for adaptation of...

11

2011-11

The researchers at Institut Pasteur of Shanghai discover different susceptibilities to Japanese encephalitis virus neuroinvasion in mice

Only a limited number of JEV-infected individuals show symptoms and induce severe encephalitis,that indicating host-dependent susceptibilities. The reason that people have different susceptibilities to JEV remains unclear. Clinical manifestations of JEV infections in laboratory mice closely resem...Japanese encephalitis virus (JEV) is a mosquito-borne flavivirus. The infectious disease it causes is encephalitis. China is one of the countries with high incidence of encephalitis. Only a limited number of JEV-infected individuals show symptoms and induce severe encephalitis, that indicating h...

28

2011-07

DIDS inhibits EV71 by targeting 2B ion channel protein

A research team led by Prof. Sun Bing, at Institute Pasteur of Shanghai (IPS), Chinese Academy of Sciences, found that an chloride channel inhibitor, DIDS could significantly block the viral production and CPE induced by enterovirus 71(EV71) which may target the 2B ion channel protein of this vir...