Research Progress--Shanghai Institut of Immunity and Infection, Chinese Academy of Sciences

12

2019-02

Discovery of molecular mechanism of DNA helicase PfRecQ1 regulating the mutually exclusive expression of virulence genes in Plasmodium falciparum

The research work, entitled "DNA helicase RecQ1 regulates mutually exclusive expression of virulence genes in Plasmodium falciparum via heterochromatin alteration" has been published online in the Journal of "Proceedings of the National Academy of Sciences of the United States" on February 6, 201...

26

2018-12

Institut Pasteur of Shanghai develops an epigenetic editing system by CRISPR/dCas9 in Plasmodium falciparum

The research work, entitled "Epigenetic editing by CRISPR/dCas9 in Plasmodium falciparum" has been published online in the Journal of "Proceedings of the National Academy of Sciences of the United States" on December 24, 2018.
　　Malaria, AIDS and tuberculosis are listed as the world's three maj...

03

2018-08

Institut Pasteur of Shanghai identifies a conserved host factor can be hijacted by pathogen to facilitate infection

Virus is one of the major infectious agents that can provoke epidemic diseases. Thus, a better understanding of the interaction between viruses and the host will provide valuable insight into prevention and treatment of viral infection. Aside from deciphering anti-virus signaling and regulators, ...

22

2018-05

Researchers of Institut Pasteur of Shanghai discovered a new mechanism underlying HCV evasion of host innate immune response

On May 22, 2018, theZhong group at Institut Pasteur of Shanghai, Chinese Academy of Sciences published online an article entitled "Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway"in PLOS Pathogens.
　　Hepatitis C virus (HCV) is one of ...