Research Progress--Shanghai Institut of Immunity and Infection, Chinese Academy of Sciences

25

2017-10

Institut Pasteur of Shanghai discovered a novel mechanism that controls the quantity and quality of mature T cells

T cell maturation in the thymus requires both positive and negative selections. Positive selection has long been considered as a default process to allow the survival of thymocytes whose T cell receptors (TCR) display intermediate-affinity to self-peptide MHC complexes (self pMHC). In contrast, h...

08

2016-01

Researchers from IPS reveal a novel mechanism of HIV-1 mucosal infection (sexual transmission)

On December 30, 2015, the Journal of Virology published an advanced research work, entitled “Human mucosal mast cells capture HIV-1 and mediate viral trans-infection of CD4+ T cells”, from Jian-Hua WANG`s Lab, Institute Pasteur of Shanghai, Chinese Academy of Sciences. This work reveals a novel...On December 30, 2015, the Journal of Virology published an advanced research work, entitled “Human mucosal mast cells capture HIV-1 and mediate viral trans-infection of CD4+ T cells”, from Jian-Hua WANG`s Lab, Institute Pasteur of Shanghai, Chinese Academy of Sciences. This work reveals a novel...

08

2016-01

Researchers at Institute Pasteur of Shanghai reveal a novel mechanism for host factors regulating HIV-1 replication

On January 6th, 2016，the Journal of Biological Chemistry published an advanced research work, entitled “HIV-1 Nef-associated factor 1 enhances viral production by interacting with CRM1 to promote nuclear export of unspliced HIV-1 gag mRNA”, from Jian-Hua WANG`s Lab, Institute Pasteur of Shang...On January 6th, 2016，Journal of Biological Chemistry published an advanced research work, entitled “HIV-1 Nef-associated factor 1 enhances viral production by interacting with CRM1 to promote nuclear export of unspliced HIV-1 gag mRNA”, from Jian-Hua WANG`s Lab, Institute Pasteur of Shanghai,...

11

2015-11

Researchers at Institut Pasteur of Shanghai identify a novel mechanism for regulation of host gene expression

Kaposi’s sarcoma-associated herpesvirus (KSHV), known as human herpesvirus 8 (HHV8), is the etiological agent of Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castelman’s disease (MCD). KSHV has developed a unique mechanism to subvert host antiviral immune responses b...Kaposi’s sarcoma-associated herpesvirus (KSHV), known as human herpesvirus 8 (HHV8), is the etiological agent of Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL) and multicentric Castelman’s disease (MCD). KSHV has developed a unique mechanism to subvert host antiviral immune responses b...