Research Progress--Shanghai Institut of Immunity and Infection, Chinese Academy of Sciences

12

2015-10

Researchers at Institut Pasteur of Shanghai identify a miRNA that promotes human Treg cell stability under inflammation

FOXP3+ Treg cells play a central role in maintaining the balance between immune tolerance and activation. Treg cells have a great plasticity and are not stable under inflammation and other physiological conditions. For instance, upon IL-6 stimulationTreg cells can lose the expression of FOXP3 and...FOXP3+ Treg cells play a central role in maintaining the balance between immune tolerance and activation. Treg cells have a great plasticity and are not stable under inflammation and other physiological conditions. For instance, upon IL-6 stimulationTreg cells can lose the expression of FOXP3 and...

29

2015-09

Researchers at Institut Pasteur of Shanghai reveal a novel function of HCoV-OC43 ns12.9 protein serves as a viroporin in morphogenesis and pathogenesis during human coronavirus infection

On September 2, Journal of Virology published a research work online entitled“The ns12.9 accessory protein of human coronavirus OC43 is a viroporin involved in virion morphogenesis and pathogenesis”from a team of researchers led by Bing Sun, Institut Pasteur of Shanghai, Chinese Academy of Scie...On September 2, Journal of Virology published a research work online entitled“The ns12.9 accessory protein of human coronavirus OC43 is a viroporin involved in virion morphogenesis and pathogenesis”from a team of researchers led by Bing Sun, Institut Pasteur of Shanghai, Chinese Academy of Scie...

11

2015-06

Researchers at Institut Pasteur of Shanghai identify a key molecular pathway for the inactivation of Treg cells after sensing inflammation

Activity of the forkhead family transcription factor FOXP3 determines the immune function of FOXP3+Regulatory T cells (Tregs). Upon infection or other inflammatory conditions, FOXP3+Tregs may suppress effector immune cell responses leading to the failure of clearing infection or autoimmunity. FOX...Activity of the forkhead family transcription factor FOXP3 determines the immune function of FOXP3+Regulatory T cells (Tregs). Upon infection or other inflammatory conditions, FOXP3+Tregs may suppress effector immune cell responses leading to the failure of clearing infection or autoimmunity. FOX...

20

2015-05

Researchers at Institut Pasteur of Shanghai discoveranew mechanism for restricting Hepatitis C Virusinfection by host innate immunity

Hepatitis C virus (HCV) is an important human pathogen that causes chronic liver diseases including hepatitis, liver cirrhosis and hepatocellular carcinoma. The tremendous progress has been achieved in the therapeutics of HCV thanks to the development of direct antiviral agents, but the worldwide...Hepatitis C virus (HCV) is an important human pathogen that causes chronic liver diseases including hepatitis, liver cirrhosis and hepatocellular carcinoma. The tremendous progress has been achieved in the therapeutics of HCV thanks to the development of direct antiviral agents, but the worldwide...